TvMP50 is an Immunogenic Metalloproteinase during Male Trichomoniasis

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TvMP50 is an immunogenic metalloproteinase during male trichomoniasis.

Trichomonas vaginalis, a human urogenital tract parasite, is capable of surviving in the male microenvironment, despite of the presence of Zn(2+). Concentrations > 1.6 mM of Zn(2+) have a trichomonacidal effect; however, in the presence of ≤1.6 mM Zn(2+), several trichomonad proteins are up- or down-regulated. Herein, we analyzed the proteome of a T. vaginalis male isolate (HGMN01) grown in the...

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TvMP50 is an Immunogenic Metalloproteinase during Male Trichomoniasis*□S

Trichomonas vaginalis, a human urogenital tract parasite, is capable of surviving in the male microenvironment, despite of the presence of Zn . Concentrations > 1.6 mM of Zn have a trichomonacidal effect; however, in the presence of <1.6 mM Zn , several trichomonad proteins are upor down-regulated. Herein, we analyzed the proteome of a T. vaginalis male isolate (HGMN01) grown in the presence of...

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Trichomoniasis.

Trichomoniasis is perhaps the most common curable sexually transmitted disease worldwide, yet few resources are devoted to its control. It is associated with potentially serious complications such as preterm birth and human immunodeficiency virus acquisition and transmission. The immunology of a related organism, Tritrichomonas foetus, which causes disease in cattle, has been investigated to so...

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Gene Polymorphism of Matrix Metalloproteinase 9 in Asthenozoospermic Male Subjects

Objective Matrix Metalloproteinase (MMPs) play important roles in the structural and functional properties of reproductive organs. The aim of this study is to determine the prevalence of C-1562T Matrix Metalloproteinase-9 (rs3918242) gene polymorphism in fertile and infertile men. In addition, we aimed to determine the association between C-1562T MMP-9 and G-1575A MMP-2 gene polymorphisms. Mate...

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[Trichomoniasis].

Few economic analyses have been made to assess the disease’s cost to the rancher. But, one study done in the late 1950’s suggested the overall loss associated with this infection could be as high as $800 per bull per year. In another more recent estimation a loss of anticipated revenue loss of $43,000 developed in a 360 cow herd the year trichomonas infection occurred. The pregnancy rate had dr...

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ژورنال

عنوان ژورنال: Molecular & Cellular Proteomics

سال: 2013

ISSN: 1535-9476

DOI: 10.1074/mcp.m112.022012